2376146-48-2

2376146-48-2 structure

Name: ZN-c3
Chemical Name: ZN-c3
CAS Number: 2376146-48-2
Molecular Formula: C₂₉H₃₄N₈O₂
Molecular Weight: 526.63
Catalog: Signaling Pathways Cell Cycle/DNA Damage Wee1
Create Date: 2021-10-22 20:28:33
Modify Date: 2024-01-06 11:24:51
ZN-c3 is an orally active, highly potent and selective Wee1 inhibitor (IC50=3.9 nM). ZN-c3 can be used for the research of cancer[1].

Name	ZN-c3

Description	ZN-c3 is an orally active, highly potent and selective Wee1 inhibitor (IC50=3.9 nM). ZN-c3 can be used for the research of cancer[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Wee1
Target	IC50: 3.9 nM (Wee1)[1]
In Vitro	ZN-c3 IC50 is 103 nM in H23c cells[1].
In Vivo	ZN-c3 (80 mg/kg; p.o.; 28 days) can effectively shrank tumors at 80 mg/kg as a single agent[1]. ZN-c3 shows excellent exposures and bioavailability in the dog PK study[1].
References	[1]. Huang PQ, et al. Discovery of ZN-c3, a Highly Potent and Selective Wee1 Inhibitor Undergoing Evaluation in Clinical Trials for the Treatment of Cancer [published online ahead of print, 2021 Aug 23]. J Med Chem. 2021;10.1021/acs.jmedchem.1c01121.