2022949-46-6
2022949-46-6 structure
- Name: Q134R
- Chemical Name: Q134R
- CAS Number: 2022949-46-6
- Molecular Formula: C22H17F3N4O
- Molecular Weight: 410.39
- Catalog: Research Areas Neurological Disease
- Create Date: 2021-11-20 23:57:26
- Modify Date: 2026-03-16 00:42:47
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Q134R, a neuroprotective hydroxyquinoline derivative that suppresses nuclear factor of activated T cell (NFAT) signaling. Q134R can across blood-brain barrier. Q134R has the potential for Alzheimer's disease (AD) and aging-related disorders research[1].
| Name | Q134R |
|---|
| Description | Q134R, a neuroprotective hydroxyquinoline derivative that suppresses nuclear factor of activated T cell (NFAT) signaling. Q134R can across blood-brain barrier. Q134R has the potential for Alzheimer's disease (AD) and aging-related disorders research[1]. |
|---|---|
| Related Catalog | |
| In Vitro | Q134R (1-10 μM) suppresses NFAT signaling, without inhibiting calcineurin activity. Q134R partially inhibits NFAT activity in primary rat astrocytes, but does not prevent calcineurin-mediated dephosphorylation of a non-NFAT target, either in vivo, or in vitro[1]. |
| In Vivo | Q134R (4 mg/kg; orally gavage; twice per day; for 7 days) treatment improves cognitive function in rodent models of AD‐like pathology[1]. Animal Model: APP/PS1 mice (12-month-old) injected with oligomeric Aβ (oAβ) peptides[1] Dosage: 4 mg/kg Administration: Orally gavage; twice per day; for 7 days Result: Led to improved Y maze performance. |
| References |
| Molecular Formula | C22H17F3N4O |
|---|---|
| Molecular Weight | 410.39 |