1414976-20-7

1414976-20-7 structure

Name: Vazegepant hydrochloride
Chemical Name: Vazegepant hydrochloride
CAS Number: 1414976-20-7
Molecular Formula: C₃₆H₄₇ClN₈O₃
Molecular Weight: 675.26
Catalog: Signaling Pathways GPCR/G Protein CGRP Receptor
Create Date: 2021-09-05 19:52:33
Modify Date: 2024-01-05 19:15:45
Vazegepant (BHV-3500) hydrochloride is a highly affinity CGRP receptor antagonist (hCGRP Ki= 0.023 nM). Vazegepant hydrochloride is the first intranasal gepant for migraine. Vazegepant hydrochloride may be helpful in effective management of COVID-19 associated pulmonary inflammation[1][2][3].

Name	Vazegepant hydrochloride

Description	Vazegepant (BHV-3500) hydrochloride is a highly affinity CGRP receptor antagonist (hCGRP Ki= 0.023 nM). Vazegepant hydrochloride is the first intranasal gepant for migraine. Vazegepant hydrochloride may be helpful in effective management of COVID-19 associated pulmonary inflammation[1][2][3].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> CGRP Receptor Signaling Pathways >> Neuronal Signaling >> CGRP Receptor Research Areas >> Infection Research Areas >> Inflammation/Immunology
Target	Ki: 0.023 nM (hCGRP)[3]
References	[1]. Moreno-Ajona D, et al. Gepants, calcitonin-gene-related peptide receptor antagonists: what could be their role in migraine treatment?. Curr Opin Neurol. 2020;33(3):309-315. [2]. Mehta PP, et al. Novel and Evolving Therapies for COVID-19 Related Pulmonary Complications. Am J Med Sci. 2021;361(5):557-566. [3]. Moreno-Ajona D, Pérez-Rodríguez A, Goadsby PJ. Gepants, calcitonin-gene-related peptide receptor antagonists: what could be their role in migraine treatment?. Curr Opin Neurol. 2020;33(3):309-315.

Molecular Formula	C₃₆H₄₇ClN₈O₃
Molecular Weight	675.26