1293289-69-6
1293289-69-6 structure
- Name: TRC160334
- Chemical Name: TRC160334
- CAS Number: 1293289-69-6
- Molecular Formula: C14H15N3O5S
- Molecular Weight: 337.35
- Catalog: Signaling Pathways Metabolic Enzyme/Protease HIF/HIF Prolyl-Hydroxylase
- Create Date: 2021-09-09 05:26:02
- Modify Date: 2024-01-15 12:41:17
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TRC160334 is a hypoxia-inducible factor (HIF) hydroxylase inhibitor. TRC160334 can be used for the research of ischemia/reperfusion injury[1].
| Name | TRC160334 |
|---|
| Description | TRC160334 is a hypoxia-inducible factor (HIF) hydroxylase inhibitor. TRC160334 can be used for the research of ischemia/reperfusion injury[1]. |
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| Related Catalog | |
| Target |
HIF hydroxylase[1] |
| In Vitro | TRC160334 (100~400 μΜ; 4 hours; Hep3B cells) results in dose-dependent stabilization of nuclear HIF-1[1]. TRC160334 (75~300 μM; 4 hours; Hep3B cells) results in dose-dependent transcriptional activation of HIF-1. TRC160334 shows a dose-dependent expression of HIF target genes such as EPO and adrenomedullin[1]. Western Blot Analysis[1] Cell Line: Hep3B cells Concentration: 100~400 μΜ Incubation Time: 4 hours Result: Resulted in dose-dependent stabilization of nuclear HIF-1. |
| In Vivo | TRC160334 (0.1 and 0.3 mg/kg; i.p.) significantly reduces serum creatinine and blood urea nitrogen[1]. TRC160334 (0.3 and 0.6 mg/kg; i.p.) shows reducing trends for acute tubular necrosis[1]. TRC160334 significantly reduces the rise in electrolyte excretion dose dependently. Preischemic treatment with TRC160334 results in a pronounced induction of HSP70 in kidneys by 6 hours while postischemic treatment with TRC160334 results in a pronounced induction of HSP70 in kidneys by 12 hours as compared with the respective vehicle control[1]. Animal Model: Sprague-Dawley male rats (250–300 g)[1] Dosage: 0.1 and 0.3 mg/kg Administration: I.p. Result: Significantly reduced serum creatinine and blood urea nitrogen. Animal Model: Sprague-Dawley male rats (250–300 g)[1] Dosage: 0.3 and 0.6 mg/kg Administration: I.p. Result: Showed reducing trends for acute tubular necrosis. |
| References |
| Molecular Formula | C14H15N3O5S |
|---|---|
| Molecular Weight | 337.35 |