501693-48-7

501693-48-7 structure

Name: TIE-2/VEGFR-2 kinase-IN-2
Chemical Name: TIE-2/VEGFR-2 kinase-IN-2
CAS Number: 501693-48-7
Molecular Formula: C₂₀H₁₃F₄N₅O₂
Molecular Weight: 431.34
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK VEGFR
Create Date: 2021-09-10 17:10:07
Modify Date: 2025-08-27 15:45:16
TIE-2/VEGFR-2 kinase-IN-2 is a potent dual VEGFR2 and Tie-2 inhibitor with pIC50 values of 8.61 and 8.56, respectively[1]. TIE-2/VEGFR-2 kinase-IN-2 is an anti-angiogenic agent and can be used for cancer research[2].

Name	TIE-2/VEGFR-2 kinase-IN-2

Description	TIE-2/VEGFR-2 kinase-IN-2 is a potent dual VEGFR2 and Tie-2 inhibitor with pIC50 values of 8.61 and 8.56, respectively[1]. TIE-2/VEGFR-2 kinase-IN-2 is an anti-angiogenic agent and can be used for cancer research[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR
Target	VEGFR-2 Tie-2
References	[1]. Yasushi Miyazaki, et al. Orally active 4-amino-5-diarylurea-furo[2,3-d]pyrimidine derivatives as anti-angiogenic agent inhibiting VEGFR2 and Tie-2. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1773-8.

Molecular Formula	C₂₀H₁₃F₄N₅O₂
Molecular Weight	431.34