859518-94-8
859518-94-8 structure
- Name: T0467
- Chemical Name: T0467
- CAS Number: 859518-94-8
- Molecular Formula: C24H26F3N5
- Molecular Weight: 441.49
- Catalog: Research Areas Neurological Disease
- Create Date: 2021-09-13 05:09:57
- Modify Date: 2025-08-26 20:44:21
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T0467 activates parkin mitochondrial translocation in a PINK1-dependent manner in vitro. T0467 do not induce mitochondrial accumulation of PINK1in dopaminergic neurons. T0467 is a potential compound for PINK1-Parkin signaling activation, and can be used for parkinson's disease and related disorders research[1].
| Name | T0467 |
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| Description | T0467 activates parkin mitochondrial translocation in a PINK1-dependent manner in vitro. T0467 do not induce mitochondrial accumulation of PINK1in dopaminergic neurons. T0467 is a potential compound for PINK1-Parkin signaling activation, and can be used for parkinson's disease and related disorders research[1]. |
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| Related Catalog | |
| In Vitro | T0467 (2.5-20 μM; 3 hours) stimulates the mitochondrial translocation of GFP-Parkinover 12 μM in HeLa/GFP-Parkin cells[1]. When HeLa/GFP-Parkin cells are treated with 20 μM T0467 for 3 h, GTP-Parkin is translocated to the mitochondria in approximately 21% of cells[1]. T0467 does not show obvious toxicity in Drosophila at concentrations <50 μM. All cpds examined mitigated the PINK1 inactivation-mediated larval locomotion defects and mitochondrial morphological defects and reduced ATP production. T0467 and KTP improved the mitochondrial Ca2+ response in Drosophila larval muscles[1]. |
| References |
| Molecular Formula | C24H26F3N5 |
|---|---|
| Molecular Weight | 441.49 |