914940-24-2

914940-24-2 structure

Name: PB2
Chemical Name: PB2
CAS Number: 914940-24-2
Molecular Formula: C₁₆H₂₀BO₂P
Molecular Weight: 286.11
Catalog: Research Areas Neurological Disease
Create Date: 2021-09-19 11:34:02
Modify Date: 2025-08-20 22:23:20
PB2 is a tris(2-carboxyethyl)phosphine (TCEP) analogue increasing retinal ganglion (RGCs) cells survival after axotomy in vitro at nanomolar and picomolar concentrations. PB2 is substantially more permeable than TCEP. PB2, as a reducing agent, is highly neuroprotective for RGCs[1].

Name	PB2

Description	PB2 is a tris(2-carboxyethyl)phosphine (TCEP) analogue increasing retinal ganglion (RGCs) cells survival after axotomy in vitro at nanomolar and picomolar concentrations. PB2 is substantially more permeable than TCEP. PB2, as a reducing agent, is highly neuroprotective for RGCs[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vitro	PB2 (0.001~100000 nM; 72 hours; RGCs) increases RGC viability[1]. PB2 has modifications that neutralize the polarity of the compounds. The methylesters of PB2 is likely to be cleaved by cytosolic esterases, yielding a polar intracellular intermediate that would be unlikely to cross cell membranes[1]. Cell Viability Assay[1] Cell Line: RGCs Concentration: 0.001~100000 nM Incubation Time: 72 hours Result: Increased RGC viability.
References	[1]. Schlieve CR, et al. Synthesis and characterization of a novel class of reducing agents that are highly neuroprotective for retinal ganglion cells. Exp Eye Res. 2006;83(5):1252-1259.

Molecular Formula	C₁₆H₂₀BO₂P
Molecular Weight	286.11