1404071-65-3

1404071-65-3 structure
1404071-65-3 structure
  • Name: Modified MMAF-C5-COOH
  • Chemical Name: Modified MMAF-C5-COOH
  • CAS Number: 1404071-65-3
  • Molecular Formula: C51H83N7O10
  • Molecular Weight: 954.25
  • Catalog: Research Areas Cancer
  • Create Date: 2021-09-13 17:06:42
  • Modify Date: 2024-01-13 16:31:59
  • Modified MMAF-C5-COOH is a drug-linker conjugate for ADC[1].

Name Modified MMAF-C5-COOH
Description Modified MMAF-C5-COOH is a drug-linker conjugate for ADC[1].
Related Catalog
In Vitro MMAF inhibits anaplastic large cell lymphoma Karpas 299, breast carcinoma H3396, renal cell carcinoma 786-O and Caki-1 cells with IC50s of 119, 105, 257 and 200 nM in vitro cytotoxicity assay[2].
References

[1]. Polson AG, et al. Antibody-drug conjugates for the treatment of non-Hodgkin's lymphoma: target and linker-drug selection [published correction appears in Cancer Res. 2010 Feb 1;70(3):1275. Slaga, Dion S [added]]. Cancer Res. 2009;69(6):2358-2364.

[2]. Doronina SO, et al. Enhanced activity of monomethylauristatin F through monoclonal antibody delivery: effects of linker technology on efficacy and toxicity. Bioconjug Chem. 2006;17(1):114-124.

Molecular Formula C51H83N7O10
Molecular Weight 954.25
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