258326-83-9
258326-83-9 structure
- Name: CGP78850
- Chemical Name: CGP78850
- CAS Number: 258326-83-9
- Molecular Formula: C36H46N5O9P
- Molecular Weight: 723.75
- Catalog: Research Areas Cancer
- Create Date: 2021-09-14 11:35:23
- Modify Date: 2025-08-26 23:38:54
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CGP78850 is a potent and selective competitor of Grb2 SH2-phosphopeptide interactions. CGP78850 can be used for the research of cancer[1].
| Name | CGP78850 |
|---|
| Description | CGP78850 is a potent and selective competitor of Grb2 SH2-phosphopeptide interactions. CGP78850 can be used for the research of cancer[1]. |
|---|---|
| Related Catalog | |
| Target |
Grb2 SH2-phosphopeptide[1] |
| In Vitro | CGP78850 (0~100 μM; 90 minutes; MDA-MB-468 cells) reduces the amount of associated Grb2 protein in a dose-dependent manner[1]. CGP78850 blocks epidermal growth factor receptor (EGFR)-Grb2 and Shc-Grb2 interaction in living cells. CGP78850 inhibits MDA-MB-468 cells to form colonies in soft agar in a dose-dependent manner[1]. Western Blot Analysis[1] Cell Line: MDA-MB-468 cells Concentration: 0~100 μM Incubation Time: 90 minutes Result: Reduced the amount of associated Grb2 protein in a dose-dependent manner. |
| References |
[1]. Gay B, et al. Selective GRB2 SH2 inhibitors as anti-Ras therapy. Int J Cancer. 1999;83(2):235-241. |
| Molecular Formula | C36H46N5O9P |
|---|---|
| Molecular Weight | 723.75 |