Shanghai Nianxing Industrial Co., Ltd
China
Product Name: AWL-II-38.3
Price: Check
Purity: 97.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: AWL-II-38.3
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

1135205-94-5

1135205-94-5 structure

1135205-94-5 structure

Name: AWL-II-38.3
Chemical Name: AWL-II-38.3
CAS Number: 1135205-94-5
Molecular Formula: C₂₃H₁₈F₃N₅O₃
Molecular Weight: 469.42
Catalog: Research Areas Cancer
Create Date: 2022-02-23 17:35:47
Modify Date: 2025-08-26 13:53:51
AWL-II-38.3 is a potent ephrin-A receptor (EphA3) kinase inhibitor. AWL-II-38.3 does not exhibit significant cellular activity against Src-family kinases nor against b-raf[1][2][1][2].

Name	AWL-II-38.3

Description	AWL-II-38.3 is a potent ephrin-A receptor (EphA3) kinase inhibitor. AWL-II-38.3 does not exhibit significant cellular activity against Src-family kinases nor against b-raf[1][2][1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
Target	Ephrin-A receptor (EphA3) kinase[1][2]
In Vitro	AWL-II-38.3 fits to LIMK2 and LIMK1 ATP-binding and substrate-binding pockets[2].
References	[1]. Yongmun Choi, et al. Discovery and structural analysis of Eph receptor tyrosine kinase inhibitors. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4467-70. [2]. Efrat Mashiach-Farkash, et al. Computer-based identification of a novel LIMK1/2 inhibitor that synergizes with salirasib to destabilize the actin cytoskeleton. Oncotarget. 2012 Jun;3(6):629-39.

Molecular Formula	C₂₃H₁₈F₃N₅O₃
Molecular Weight	469.42

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