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1135205-94-5

1135205-94-5 structure
1135205-94-5 structure
  • Name: AWL-II-38.3
  • Chemical Name: AWL-II-38.3
  • CAS Number: 1135205-94-5
  • Molecular Formula: C23H18F3N5O3
  • Molecular Weight: 469.42
  • Catalog: Research Areas Cancer
  • Create Date: 2022-02-23 17:35:47
  • Modify Date: 2024-01-13 22:03:37
  • AWL-II-38.3 is a potent ephrin-A receptor (EphA3) kinase inhibitor. AWL-II-38.3 does not exhibit significant cellular activity against Src-family kinases nor against b-raf[1][2][1][2].
Name AWL-II-38.3
Description AWL-II-38.3 is a potent ephrin-A receptor (EphA3) kinase inhibitor. AWL-II-38.3 does not exhibit significant cellular activity against Src-family kinases nor against b-raf[1][2][1][2].
Related Catalog
Target

Ephrin-A receptor (EphA3) kinase[1][2]

In Vitro AWL-II-38.3 fits to LIMK2 and LIMK1 ATP-binding and substrate-binding pockets[2].
References

[1]. Yongmun Choi, et al. Discovery and structural analysis of Eph receptor tyrosine kinase inhibitors. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4467-70.

[2]. Efrat Mashiach-Farkash, et al. Computer-based identification of a novel LIMK1/2 inhibitor that synergizes with salirasib to destabilize the actin cytoskeleton. Oncotarget. 2012 Jun;3(6):629-39.
Molecular Formula C23H18F3N5O3
Molecular Weight 469.42

Chemsrc provides CAS#:1135205-94-5 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 1135205-94-5 | Chemsrc address: https://www.chemsrc.com/en/baike/1681234.html

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