117094-40-3
117094-40-3 structure
- Name: LCAHA
- Chemical Name: LCAHA
- CAS Number: 117094-40-3
- Molecular Formula: C24H41NO3
- Molecular Weight: 391.59
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Deubiquitinase
- Create Date: 2021-09-24 19:23:08
- Modify Date: 2024-01-11 10:28:19
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LCAHA (LCA hydroxyamide) is a deubiquitinase USP2a inhibitor with IC50s of 9.7 μM and 3.7μM in Ub-AMC Assay and Di-Ub Assay, respectively. LCAHA destabilizes Cyclin D1 and induces G0/G1 arrest by inhibiting deubiquitinase USP2a[1].
| Name | LCAHA |
|---|
| Description | LCAHA (LCA hydroxyamide) is a deubiquitinase USP2a inhibitor with IC50s of 9.7 μM and 3.7μM in Ub-AMC Assay and Di-Ub Assay, respectively. LCAHA destabilizes Cyclin D1 and induces G0/G1 arrest by inhibiting deubiquitinase USP2a[1]. |
|---|---|
| Related Catalog | |
| In Vitro | LCAHA inhibits HCT116wt and HCT116 p53-/- colon cancer cells viability with GI50s of 0.87±0.09 and 0.96±0.29μM, respectively, and the LD50s of 27.8±3.9 and 26.5±0.1μM, respectively[1]. Cell Viability Assay[1] Cell Line: HCT116wt and HCT116 p53-/- colon cancer cells Concentration: 0.01, 0.1, 1, 10, and 100 μM Incubation Time: 6 days Result: The GI50s are 0.87±0.09 and 0.96±0.29 μM for HCT116wt and HCT116 p53-/- colon cancer cells, respectively. |
| References |
| Molecular Formula | C24H41NO3 |
|---|---|
| Molecular Weight | 391.59 |