1146534-45-3

1146534-45-3 structure

Name: Aminohexylgeldanamycin hydrochloride
Chemical Name: Aminohexylgeldanamycin hydrochloride
CAS Number: 1146534-45-3
Molecular Formula: C₃₄H₅₃ClN₄O₈
Molecular Weight: 681.26
Catalog: Signaling Pathways Antibody-drug Conjugate ADC Cytotoxin
Create Date: 2021-09-06 08:49:43
Modify Date: 2024-01-12 21:26:17
Aminohexylgeldanamycin (AHGDM) hydrochloride, a Geldanamycin derivative, is a potent HSP90 inhibitor. Aminohexylgeldanamycin hydrochloride shows antiangiogenic and antitumor activities[1].

Name	Aminohexylgeldanamycin hydrochloride

Description	Aminohexylgeldanamycin (AHGDM) hydrochloride, a Geldanamycin derivative, is a potent HSP90 inhibitor. Aminohexylgeldanamycin hydrochloride shows antiangiogenic and antitumor activities[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> HSP Signaling Pathways >> Antibody-drug Conjugate >> ADC Cytotoxin Signaling Pathways >> Cell Cycle/DNA Damage >> HSP
Target	HSP90
In Vitro	HPMA copolymer-aminohexylgeldanamycin conjugates target cell surface expressed GRP78 in prostate cancer[2].
References	[1]. Greish K, et al. Anticancer and antiangiogenic activity of HPMA copolymer-aminohexylgeldanamycin-RGDfK conjugates for prostate cancer therapy. J Control Release. 2011;151(3):263-270. [2]. Larson N, et al. HPMA copolymer-aminohexylgeldanamycin conjugates targeting cell surface expressed GRP78 in prostate cancer. Pharm Res. 2010;27(12):2683-2693.

Molecular Formula	C₃₄H₅₃ClN₄O₈
Molecular Weight	681.26