2569009-58-9
2569009-58-9 structure
- Name: PF-9363
- Chemical Name: PF-9363
- CAS Number: 2569009-58-9
- Molecular Formula: C20H20N4O6S
- Molecular Weight: 444.46
- Catalog: Signaling Pathways Epigenetics Histone Acetyltransferase
- Create Date: 2021-09-05 16:54:15
- Modify Date: 2025-08-28 02:15:28
-
PF-9363 (CTx-648) is a first-in-class potent and high selective KAT6A/KAT6B inhibitor. PF-9363 can be used for the research of cancer[1][2].
| Name | PF-9363 |
|---|---|
| Synonyms | Benzenesulfonamide, 2,6-dimethoxy-N-[4-methoxy-6-(1H-pyrazol-1-ylmethyl)-1,2-benzisoxazol-3-yl]- |
| Description | PF-9363 (CTx-648) is a first-in-class potent and high selective KAT6A/KAT6B inhibitor. PF-9363 can be used for the research of cancer[1][2]. |
|---|---|
| Related Catalog | |
| Target |
KAT6A/KAT6B[1] |
| In Vitro | PF-9363 (0~1 μM; 1 day; ZR75-1, T47D and MCF7 cells) down-regulates the expression of H3K23Ac biomarker[1]. PF-9363 leads to down regulation of a specific set of genes involved in ESR1 pathway, cell cycle and stem cell pathways. PF-9363 shows that the IC50 values for ZR75-1 and T47D are 0.3 nM and 0.9 nM[1]. Western Blot Analysis[1] Cell Line: ZR75-1, T47D and MCF7 cells Concentration: 0~1 μM Incubation Time: 1 day Result: Down-regulated the expression of H3K23Ac biomarker. |
| In Vivo | PF-9363 shows strong anti-tumor activity in patient-derived xenograft models[1]. |
| References |
[2]. WO2020254946 |
| Molecular Formula | C20H20N4O6S |
|---|---|
| Molecular Weight | 444.46 |
| Storage condition | -20°C |
| Hazard Codes | Xn |
|---|