140932-79-2
140932-79-2 structure
- Name: balhimycin
- Chemical Name: (1S,2R,18R,19R,22S,25R,28R,40S)-2-{[(2R,4S,6S)-4-Amino-5,5-dihydroxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-22-(2-amino-2-oxoethyl)-5,15-dichloro-18,32,35,37-tetrahydroxy-19-{[(2R)-4-methyl-2-(methylamino)pentanoyl]amino}-20,23,26,42,44-pentaoxo-48-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-7,13-dioxa-21,24,27,41,43-pentaazaoctacyclo[26.14.2.23,6.214,17.18,12.129,33.010,25.034,39]pentac
- CAS Number: 140932-79-2
- Molecular Formula: C66H75Cl2N9O25
- Molecular Weight: 1465.253
- Catalog: Signaling Pathways Anti-infection Bacterial
- Create Date: 2021-09-10 11:34:51
- Modify Date: 2024-01-09 09:32:44
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Balhimycin is a glycopeptide antibiotic, found from the fermentation broth of a Amycolatopsis sp. Balhimycin shows anti-bacterial activity against staphylococci and anaerobes[1].
| Name | (1S,2R,18R,19R,22S,25R,28R,40S)-2-{[(2R,4S,6S)-4-Amino-5,5-dihydroxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-22-(2-amino-2-oxoethyl)-5,15-dichloro-18,32,35,37-tetrahydroxy-19-{[(2R)-4-methyl-2-(methylamino)pentanoyl]amino}-20,23,26,42,44-pentaoxo-48-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-7,13-dioxa-21,24,27,41,43-pentaazaoctacyclo[26.14.2.23,6.214,17.18,12.129,33.010,25.034,39]pentac |
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| Synonyms | (1S,2R,18R,19R,22S,25R,28R,40S)-2-{[(2R,4S,6S)-4-Amino-5,5-dihydroxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-22-(2-amino-2-oxoethyl)-5,15-dichloro-18,32,35,37-tetrahydroxy-19-{[(2R)-4-methyl-2-(meth ;ylamino)pentanoyl]amino}-20,23,26,42,44-pentaoxo-48-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}-7,13-dioxa-21,24,27,41,43-pentaazaoctacyclo[26.14.2.23,6.214,1 7.18,12.129,33.010,25.034,39]pentac |
| Description | Balhimycin is a glycopeptide antibiotic, found from the fermentation broth of a Amycolatopsis sp. Balhimycin shows anti-bacterial activity against staphylococci and anaerobes[1]. |
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| Related Catalog | |
| Target |
Glycopeptide |
| In Vitro | Balhimycin (0.39-12.5 μg/mL; 18 h) shows bactericidal activity against S. aureus, Streptococcus epidermidis, and streptococcal strains[1]. Balhimycin (0.39-12.5 μg/mL; 18 h) shows good bactericidal activity against different Staphylococcal strains[1]. Balhimycin (1-15 μg/mL; 30 min) leads to cell membrane scrambling of platelets, and shows stimulation of platelet apoptosis[2] Cell Viability Assay[1] Cell Line: Staphylococcus aureus 209P, S. aureus 3066, S. aureus 20424, S. epidermidis 178, S. epidermidis 825, S. epidermidis 823, S. haemolyticus 712, S. haemolyticus 809, Streptococcus ATCC 29212, S. faecalis D 21777, S. faecalis D Endococcen, S. faecium D-59, S. faecium D-65 Concentration: 0.39-12.5 μg/mL Incubation Time: 18 hours Result: Showed MIC values ranging from 0.39 μg/mL to 12.5 μg/mL against S. aureus, Streptococcus epidermidis, and streptococcal strains. Cell Viability Assay[1] Cell Line: Staphylococcus aureus 3066, S. aureus 20424, S. epidermidis 825, S. haemolyticus 712, Streptococcus faecalis ATCC29212, S. faecalis D 21777, S. faecalis D-59 Concentration: 0.39-1.56 μg/mL Incubation Time: 18 hours Result: Showed MIC values ranging from 0.39 μg/mL to 1.56 μg/mL against staphylococcal strains. |
| Density | 1.7±0.1 g/cm3 |
|---|---|
| Molecular Formula | C66H75Cl2N9O25 |
| Molecular Weight | 1465.253 |
| Exact Mass | 1463.425171 |
| LogP | -0.44 |
| Index of Refraction | 1.743 |