88979-61-7
88979-61-7 structure
- Name: Bafilomycin C1
- Chemical Name: bafilomycin c1
- CAS Number: 88979-61-7
- Molecular Formula: C39H60O12
- Molecular Weight: 720.88600
- Catalog: Signaling Pathways Anti-infection Bacterial
- Create Date: 2016-12-15 15:43:44
- Modify Date: 2024-01-05 12:48:00
-
Bafilomycin C1 is a macrolide antibiotic isolated from Streptomyces sp. Bafilomycin C1 is a potent, specific and reversible inhibitor of vacuolar-type H+-ATPases (V-ATPases). Bafilomycin C1 inhibits growth of gram-positive bacteria and fungi[2]. Bafilomycin C1 induces cell apoptosis and can be used for the study of hepatocellular carcinoma (HCC)[2].
| Name | bafilomycin c1 |
|---|---|
| Synonyms | 2-Demethyl-2-methoxy-24-methylhygrolidin |
| Description | Bafilomycin C1 is a macrolide antibiotic isolated from Streptomyces sp. Bafilomycin C1 is a potent, specific and reversible inhibitor of vacuolar-type H+-ATPases (V-ATPases). Bafilomycin C1 inhibits growth of gram-positive bacteria and fungi[2]. Bafilomycin C1 induces cell apoptosis and can be used for the study of hepatocellular carcinoma (HCC)[2]. |
|---|---|
| Related Catalog | |
| In Vitro | Bafilomycin C1 (0.33-10 μM; 6 days) inhibits the growth and proliferation of SMMC7721 and HepG2 cells in a timeand dose-dependent manner[2]. Bafilomycin C1 (0.33-3.3 μM; 24 hours) decreases cyclin D3, cyclin E1, CDK2, CDK4, and CDK6 expression in both mRNA and protein expression in SMMC7721 cells[2]. Bafilomycin C1 (3.3-10 μM; 24 hours) causes morphological alterations and increases the population of apoptotic cells by Hoechst 33258 (HY-15558) staining compared to vehicle[2]. Cell Viability Assay[2] Cell Line: SMMC7721 cell and HepG2 cell Concentration: 0.33 μM, 1.1 μM, and 3.3 μM for SMMC7721 1.1 μM, 3.3 μM, and 10.0 μM for HepG2 Incubation Time: 6 days Result: Retarded the cell growth. Western Blot Analysis[2] Cell Line: SMMC7721 cells Concentration: 3.3 μM Incubation Time: 24 hours Result: Decreaed cyclin D3/E1,CDK2/4/6 protein expression and increased p21. Apoptosis Analysis[2] Cell Line: SMMC7721 and HepG2 cells Concentration: 3.3 μM; 10 μM Incubation Time: 24 hours Result: Induced apoptosis in SMMC7721 and HepG2 cells. |
| In Vivo | Bafilomycin C1 (subcutaneous injection; 0.2 mg/kg; 20 days) retards the tumor growth without apparent adverse reactions or side effects in nude mice model[1]. Animal Model: BALB/c nude mice (weighing 18-20 g) subcutaneous injected by SMMC7721 cell suspension (5×106 cells/100 μL)[2] Dosage: 0.2 mg/kg Administration: Subcutaneous injection; 20 days Result: Suppressed tumor growth of SMMC7721 tumor xenografts. |
| References |
| Density | 1.18 g/cm3 |
|---|---|
| Boiling Point | 844.4ºC at 760 mmHg |
| Molecular Formula | C39H60O12 |
| Molecular Weight | 720.88600 |
| Flash Point | 248.9ºC |
| Exact Mass | 720.40800 |
| PSA | 178.28000 |
| LogP | 4.88440 |
| Index of Refraction | 1.544 |