Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 4-(2,4-Dichlorophenyl)-1,4-dihydro-[1,3,5]triazino[1,2-a]benzimidazol-2-amine
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305343-00-4

305343-00-4 structure

Name: 4-(2,4-Dichlorophenyl)-1,4-dihydro-[1,3,5]triazino[1,2-a]benzimidazol-2-amine
Chemical Name: 4-(2,4-Dichlorophenyl)-4,10-dihydro[1,3,5]triazino[1,2-a]benzimidazol-2-amine
CAS Number: 305343-00-4
Molecular Formula: C₁₅H₁₁Cl₂N₅
Molecular Weight: 332.19
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2021-09-13 08:40:37
Modify Date: 2025-09-15 19:51:01
Topoisomerase II inhibitor 14 (compound 2f) is a potent inhibtor of Topoisomerase II, with anticancer activity. Topoisomerase II inhibitor 14 induces apoptosis, and arrests cell cycle at S phase. Topoisomerase II inhibitor 14 exhibits antioxidant effect and decreases the level of GSH, MDA, and NO[1].

Name	4-(2,4-Dichlorophenyl)-4,10-dihydro[1,3,5]triazino[1,2-a]benzimidazol-2-amine
Synonyms	1,3,5-triazino[1,2-a]benzimidazol-2-amine, 4-(2,4-dichlorophenyl)-3,4-dihydro- 1,3,5-Triazino[1,2-a]benzimidazol-2-amine, 4-(2,4-dichlorophenyl)-4,10-dihydro- 4-(2,4-Dichlorophenyl)-4,10-dihydro[1,3,5]triazino[1,2-a]benzimidazol-2-amine MFCD06592467

Description	Topoisomerase II inhibitor 14 (compound 2f) is a potent inhibtor of Topoisomerase II, with anticancer activity. Topoisomerase II inhibitor 14 induces apoptosis, and arrests cell cycle at S phase. Topoisomerase II inhibitor 14 exhibits antioxidant effect and decreases the level of GSH, MDA, and NO[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase
In Vivo	Topoisomerase II inhibitor 14 (compound 2f)
References	[1]. Al-Karmalawy AA, et al. Novel fused imidazotriazines acting as promising top. II inhibitors and apoptotic inducers with greater selectivity against head and neck tumors: Design, synthesis, and biological assessments. Eur J Med Chem. 2023 Nov 5;259:115661.