13060-15-6

13060-15-6 structure

Name: Aschantin
Chemical Name: (+)-Aschantin
CAS Number: 13060-15-6
Molecular Formula: C₂₂H₂₄O₇
Molecular Weight: 400.42
Catalog: Signaling Pathways Metabolic Enzyme/Protease Cytochrome P450
Create Date: 2021-09-17 00:24:12
Modify Date: 2025-08-25 11:07:23
Aschantin, a bisepoxylignan, can be isolated from Magnolia biondii. Aschantin has antiplasmodial, Ca2+-antagonistic, platelet activating factor-antagonistic, and chemopreventive activities. Aschantin is a mTOR kinase inhibitor. Aschantin is also an inhibitor of Cytochrome P450 and UGT enzyme[1][2].

Name	(+)-Aschantin
Synonyms	(+)-Aschantin 5-[(1S,3aR,4S,6aR)-4-(3,4,5-Trimethoxyphenyl)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]-1,3-benzodioxole 1,3-Benzodioxole, 5-[(1S,3aR,4S,6aR)-tetrahydro-4-(3,4,5-trimethoxyphenyl)-1H,3H-furo[3,4-c]furan-1-yl]-

Description	Aschantin, a bisepoxylignan, can be isolated from Magnolia biondii. Aschantin has antiplasmodial, Ca2+-antagonistic, platelet activating factor-antagonistic, and chemopreventive activities. Aschantin is a mTOR kinase inhibitor. Aschantin is also an inhibitor of Cytochrome P450 and UGT enzyme[1][2].
Related Catalog	Signaling Pathways >> PI3K/Akt/mTOR >> mTOR Research Areas >> Cancer Research Areas >> Cardiovascular Disease Research Areas >> Infection Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450
References	[1]. Lee CJ, et al. Aschantin targeting on the kinase domain of mammalian target of rapamycin suppresses epidermal growth factor-induced neoplastic cell transformation. Carcinogenesis. 2015 Oct;36(10):1223-34. [2]. Kwon SS, et al. Inhibitory Effects of Aschantin on Cytochrome P450 and Uridine 5'-diphospho-glucuronosyltransferase Enzyme Activities in Human Liver Microsomes. Molecules. 2016 Apr 27;21(5):554.