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382-67-2 61618-63-1
1234572-33-8

382-67-2

382-67-2 structure
382-67-2 structure
  • Name: Desoximetasone
  • Chemical Name: desoximetasone
  • CAS Number: 382-67-2
  • Molecular Formula: C22H29FO4
  • Molecular Weight: 376.462
  • Catalog: analytical chemistry Standard Forensic and veterinary standards
  • Create Date: 2018-02-14 08:00:00
  • Modify Date: 2024-01-03 19:34:16
  • Desoximetasone(Topicort) is a medication belonging to the family of medications known as topical corticosteroids; is used for the relief of various skin conditions, including rashes.IC50 value:Target: When using desoximetasone, some of the medication may be absorbed through the skin and into the bloodstream. Too much absorption can lead to unwanted side effects elsewhere in the body. To keep this problem to a minimum, avoid using large amounts of desoximetasone over large areas, do not use it for extended periods of time, and do not cover it with airtight dressings such as plastic wrap or adhesive bandages unless specifically told to by your doctor.[1] Children may absorb more medication than adults do. Desoximetasone is for use only on the skin and should be kept out of the eyes.
Name desoximetasone
Synonyms desoximetasonum [INN_la]
Desoximetasone
EINECS 206-845-3
9-Fluoro-11-β,21-dihydroxy-16-α-methylpregna-1,4-diene-3,20-dione
MFCD00083301
desoximetasona [INN_es]
(11β,16α)-9-Fluoro-11,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione
Pregna-1,4-diene-3,20-dione, 9-fluoro-11,21-dihydroxy-16-methyl-, (11β,16α)-
desoximetasone [INN_en]
Desoxymetasone
Description Desoximetasone(Topicort) is a medication belonging to the family of medications known as topical corticosteroids; is used for the relief of various skin conditions, including rashes.IC50 value:Target: When using desoximetasone, some of the medication may be absorbed through the skin and into the bloodstream. Too much absorption can lead to unwanted side effects elsewhere in the body. To keep this problem to a minimum, avoid using large amounts of desoximetasone over large areas, do not use it for extended periods of time, and do not cover it with airtight dressings such as plastic wrap or adhesive bandages unless specifically told to by your doctor.[1] Children may absorb more medication than adults do. Desoximetasone is for use only on the skin and should be kept out of the eyes.
Related Catalog
References

[1]. Desoximetasone, From Wikipedia
Density 1.3±0.1 g/cm3
Boiling Point 532.3±50.0 °C at 760 mmHg
Melting Point 217ºC
Molecular Formula C22H29FO4
Molecular Weight 376.462
Flash Point 275.7±30.1 °C
Exact Mass 376.204987
PSA 74.60000
LogP 2.20
Vapour Pressure 0.0±3.2 mmHg at 25°C
Index of Refraction 1.574
Storage condition Refrigerator

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TU3834000
CHEMICAL NAME :
Pregna-1,4-diene-3,20-dione, 9-fluoro-11-beta,21-dihydroxy-16-alpha-methyl-
CAS REGISTRY NUMBER :
382-67-2
LAST UPDATED :
199612
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C22-H29-F-O4
MOLECULAR WEIGHT :
376.51
WISWESSER LINE NOTATION :
L E5 B666 OV AHTTT&J A1 BF CQ E1 FV1Q G1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
225 ug/kg
SEX/DURATION :
female 8-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 71,367,1975
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
900 ug/kg
SEX/DURATION :
female 8-16 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 71,367,1975
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
4800 ug/kg
SEX/DURATION :
female 7-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 71,367,1975
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
3600 ug/kg
SEX/DURATION :
female 7-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 71,367,1975
Symbol GHS07 GHS08
GHS07, GHS08
Signal Word Warning
Hazard Statements H302-H312-H315-H317-H319-H332-H335-H351
Precautionary Statements P261-P280-P305 + P351 + P338
Personal Protective Equipment Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes Xn:Harmful;
Risk Phrases R20/21/22;R36/37/38;R40;R43
Safety Phrases S22-S26-S36
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS TU3834000
HS Code 2914700090
50-02-2 structure

50-02-2

~83%

382-67-2 structure

382-67-2
Literature: TARO PHARMACEUTICAL INDUSTRIES LTD.; CHERNIAK, Simon; CYJON, Rosa; OZER, Ilana; NUDELMAN, Igor Patent: WO2012/11106 A1, 2012 ; Location in patent: Page/Page column 15-16 ;
Precursor  1

DownStream  1

HS Code 2914700090
Summary HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0%

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