946369-04-6

946369-04-6 structure

Name: TG53
Chemical Name: 5-Chloro-N-(4-{[4-(dimethylamino)-6-methyl-2-pyrimidinyl]amino}phenyl)-2-methoxybenzamide
CAS Number: 946369-04-6
Molecular Formula: C₂₁H₂₂ClN₅O₂
Molecular Weight: 411.88
Catalog: Signaling Pathways Cytoskeleton Integrin
Create Date: 2021-09-13 17:03:16
Modify Date: 2025-08-24 23:02:25
TG53 is a potent inhibitor of tissue transglutaminase (TG2) and fibronectin (FN) protein-protein interaction. TG53 inhibits formation of a complex with integrin β1 and activation of FAK and c-Src during SKOV3 cell attachment onto FN. TG53 can be used for ovarian cancer research[1].

Name	5-Chloro-N-(4-{[4-(dimethylamino)-6-methyl-2-pyrimidinyl]amino}phenyl)-2-methoxybenzamide
Synonyms	5-Chloro-N-(4-{[4-(dimethylamino)-6-methyl-2-pyrimidinyl]amino}phenyl)-2-methoxybenzamide Benzamide, 5-chloro-N-[4-[[4-(dimethylamino)-6-methyl-2-pyrimidinyl]amino]phenyl]-2-methoxy-

Description	TG53 is a potent inhibitor of tissue transglutaminase (TG2) and fibronectin (FN) protein-protein interaction. TG53 inhibits formation of a complex with integrin β1 and activation of FAK and c-Src during SKOV3 cell attachment onto FN. TG53 can be used for ovarian cancer research[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FAK Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Src Signaling Pathways >> Cytoskeleton >> Integrin
References	[1]. Gary E. Schiltz, et al. Inhibitors of tissue transglutaminase 2 (tg2) and uses thereof. Patent, US20210276960A1. 09/09/2021.