945008-17-3

945008-17-3 structure

Name: TM6008
Chemical Name: 6-Amino-1,3-dimethyl-5-{[2-(2-pyridinyl)-4-quinolinyl]carbonyl}-2,4(1H,3H)-pyrimidinedione
CAS Number: 945008-17-3
Molecular Formula: C₂₁H₁₇N₅O₃
Molecular Weight: 387.39
Create Date: 2021-09-12 20:17:12
Modify Date: 2025-09-20 18:58:27
TM6008 is a potent and orally active prolyl hydroxylase (PHD) inhibitor. TM6008 chelats transition metal (copper) and inhibits the autoxidation of ascorbic acid with an IC50 value is 0.57 μM. TM6008 exerts organ protection against ischemia in vivo and can be used for cerebrovascular disease research[1].

Name	6-Amino-1,3-dimethyl-5-{[2-(2-pyridinyl)-4-quinolinyl]carbonyl}-2,4(1H,3H)-pyrimidinedione
Synonyms	2,4(1H,3H)-Pyrimidinedione, 6-amino-1,3-dimethyl-5-[[2-(2-pyridinyl)-4-quinolinyl]carbonyl]- MFCD06328076 6-Amino-1,3-dimethyl-5-{[2-(2-pyridinyl)-4-quinolinyl]carbonyl}-2,4(1H,3H)-pyrimidinedione

Description	TM6008 is a potent and orally active prolyl hydroxylase (PHD) inhibitor. TM6008 chelats transition metal (copper) and inhibits the autoxidation of ascorbic acid with an IC50 value is 0.57 μM. TM6008 exerts organ protection against ischemia in vivo and can be used for cerebrovascular disease research[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> HIF/HIF Prolyl-Hydroxylase
In Vivo	TM6008 (p.o.; 50 mg/kg; single dosage) exhibits plasma Tmax, Cmax, and T1/2 values of 3.5 hour, 0.9 μg/mL and 1.5 hour for TM6008 in rat[1]. TM6008 (p.o.; 100 mg/kg; 7 days) protects against hypoxia-induced apoptotic neuronal death and decreases the number of apoptotic cells in Gerbils after a 5-minute transient global cerebral ischemia[1]. Animal Model: Gerbils after a 5-minute transient global cerebral ischemia[1] Dosage: 100 mg/kg Administration: p.o.; 100 mg/kg; 7 days Result: Exerted organ protection against ischemia in vivo.
References	[1]. Masaomi Nangaku, et al. A novel class of prolyl hydroxylase inhibitors induces angiogenesis and exerts organ protection against ischemia. Arterioscler Thromb Vasc Biol. 2007 Dec;27(12):2548-54.