Name | ADTL-EI1712 |
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Synonyms |
2-[(2-Chlorobenzoyl)amino]-6-[(2-chlorophenyl)carbamothioyl]-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide
Thieno[2,3-c]pyridine-3-carboxamide, 2-[(2-chlorobenzoyl)amino]-6-[[(2-chlorophenyl)amino]thioxomethyl]-4,5,6,7-tetrahydro- ADTL-EI1712 |
Description | ADTL-EI1712 is a potent, orally active, and selective dual-target inhibitor of ERK1 and ERK5, inhibition rates of ERK1/5 at 1 μM are 93.54% and 89.35%, respectively. ADTL-EI1712 can induce regulated cell death, a form of cell death that relies on the activation of genetically encoded machinery, to overcome compensatory mechanism in specific cancer cells in vitro and in vivo[1]. |
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Related Catalog | |
References |
Density | 1.6±0.1 g/cm3 |
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Molecular Formula | C22H18Cl2N4O2S2 |
Molecular Weight | 505.440 |
Exact Mass | 504.024811 |
LogP | 4.08 |
Index of Refraction | 1.768 |