1426173-65-0

1426173-65-0 structure

Name: Ampicillin-d5
Chemical Name: Ampicillin-d5
CAS Number: 1426173-65-0
Molecular Formula: C₁₆H₁₄D₅N₃O₄S
Molecular Weight: 354.436
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2021-06-21 13:33:48
Modify Date: 2024-01-02 14:28:22
Ampicillin-d5 (D-(-)-α-Aminobenzylpenicillin-d5) is the deuterium labeled Ampicillin. Ampicillin is a broad-spectrum beta-lactam antibiotic against a variety of gram-positive and gram-negative bacteria[1][2][3].

Name	Ampicillin-d5
Synonyms	4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2R)-2-amino-2-(phenyl-d5)acetyl]amino]-3,3-dimethyl-7-oxo-, (2S,5R,6R)- (2S,5R,6R)-6-{[(2R)-2-Amino-2-(2H5)phenylacetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid MFCD19704897

Description	Ampicillin-d5 (D-(-)-α-Aminobenzylpenicillin-d5) is the deuterium labeled Ampicillin. Ampicillin is a broad-spectrum beta-lactam antibiotic against a variety of gram-positive and gram-negative bacteria[1][2][3].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Chopra SL, et al. Effect of Ampicillin on E. Coli of Swine Origin. Can J Comp Med Vet Sci. 1963 Sep;27(9):223-7. [3]. Lund B, et al. Ampicillin in portal and peripheral blood and bile after oral administration of ampicillin andpivampicillin. Eur J Clin Pharmacol. 1974;7(2):133-5. [4]. Lee KE, et al. The neuroprotective mechanism of ampicillin in a mouse model of transient forebrain ischemia. Korean J Physiol Pharmacol. 2016 Mar;20(2):185-92.