1831135-30-8

1831135-30-8 structure

Name: JJH260
Chemical Name: JJH260
CAS Number: 1831135-30-8
Molecular Formula: C₂₉H₃₄ClN₅O₅
Molecular Weight: 568.06
Catalog: Signaling Pathways Metabolic Enzyme/Protease MAGL
Create Date: 2021-05-10 20:24:35
Modify Date: 2022-02-07 22:10:36
JJH260 is AIG1inhibitor, and inhibit the fluorophosphonate reactivity and fatty acid esters of hydroxy fatty acid (FAHFA) hydrolysis activity of AIG1in HEK293T cells, with IC50 values of 0.50 μM and 0.57 μM, respectively[1].

Name	JJH260
Synonyms	Imidazo[1,5-a]pyrazine-1,3(2H,5H)-dione, 2-[[[4-[2-(4-chlorophenyl)ethyl]-1-piperidinyl]carbonyl]oxy]-7-[4-(dimethylamino)benzoyl]tetrahydro- 2-[({4-[2-(4-Chlorophenyl)ethyl]-1-piperidinyl}carbonyl)oxy]-7-[4-(dimethylamino)benzoyl]tetrahydroimidazo[1,5-a]pyrazine-1,3(2H,5H)-dione JJH260

Description	JJH260 is AIG1inhibitor, and inhibit the fluorophosphonate reactivity and fatty acid esters of hydroxy fatty acid (FAHFA) hydrolysis activity of AIG1in HEK293T cells, with IC50 values of 0.50 μM and 0.57 μM, respectively[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> MAGL Research Areas >> Metabolic Disease Signaling Pathways >> Others >> Androgen Receptor
Target	0.50 μM (AIG1) and 0.57 μM (FAHFA) in HEK293T cells [1]
References	[1]. William H Parsons, et al. AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs. Nat Chem Biol. 2016 May;12(5):367-372. [2]. Xinkang Wang, et al. Antithrombotic Effects of the Novel Small-Molecule Factor XIa Inhibitor Milvexian in a Rabbit Arteriovenous Shunt Model of Venous Thrombosis. TH Open. 2023 Apr; 7(2): e97–e104.