932191-62-3

932191-62-3 structure

Name: ISAM 140
Chemical Name: ISAM-140
CAS Number: 932191-62-3
Molecular Formula: C₁₉H₁₉N₃O₃
Molecular Weight: 337.37
Catalog: Signaling Pathways GPCR/G Protein Adenosine Receptor
Create Date: 2021-01-09 11:55:34
Modify Date: 2024-01-10 20:58:07
ISAM-140 (22b) is a potent and highly selective A2B adenosine receptor antagonist with a Ki of 3.49 nM[1].

Name	ISAM-140
Synonyms	Isopropyl 4-(2-furyl)-2-methyl-4,10-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate Isopropyl 4-(2-furyl)-2-methyl-1,4-dihydropyrimido[1,2-a]benzimidazole-3-carboxylate Pyrimido[1,2-a]benzimidazole-3-carboxylic acid, 4-(2-furanyl)-1,4-dihydro-2-methyl-, 1-methylethyl ester Pyrimido[1,2-a]benzimidazole-3-carboxylic acid, 4-(2-furanyl)-4,10-dihydro-2-methyl-, 1-methylethyl ester MFCD09438096 4-(2-Furanyl)-4,10-dihydro-2-methyl-pyrimido[1,2-a]benzimidazole-3-carboxylic acid 1-methylethyl ester ISAM-140 (±)-Isopropyl 4-(Furan-2-yl)-2-methyl-1,4-dihydrobenzo-[4,5]imidazo[1,2-a]pyrimidine-3-carboxylate

Description	ISAM-140 (22b) is a potent and highly selective A2B adenosine receptor antagonist with a Ki of 3.49 nM[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor
Target	hA2B:3.49 nM (Ki)
In Vitro	ISAM-140 (22b) (0.1-100 µM) inhibits NECA (5'-N-ethylcarboxamido adenosine)-stimulated cAMP accumulation[1]. ISAM-140 shows a KB value of 27.00 nM[1].
References	[1]. El Maatougui A, et al. Discovery of Potent and Highly Selective A2B Adenosine Receptor Antagonist Chemotypes. J Med Chem. 2016 Mar 10;59(5):1967-83.