852045-46-6

852045-46-6 structure

Name: Flt-3 Inhibitor III
Chemical Name: FLT3 Inhibitor III
CAS Number: 852045-46-6
Molecular Formula: C₂₁H₂₃N₃OS
Molecular Weight: 365.492
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK FLT3
Create Date: 2021-02-03 17:47:29
Modify Date: 2025-08-26 09:23:20
Flt-3 Inhibitor III is a potent and selective FLT3 kinase inhibitor with an 50 of 50 nM. Flt-3 Inhibitor III shows less active against other kinases. Flt-3 Inhibitor III has anticancer effects[1].

Name	FLT3 Inhibitor III
Synonyms	FLT3 Inhibitor III 2-Thiazolamine, 5-phenyl-N-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]- 5-Phenyl-N-{4-[2-(1-pyrrolidinyl)ethoxy]phenyl}-1,3-thiazol-2-amine Flt-3 Inhibitor III

Description	Flt-3 Inhibitor III is a potent and selective FLT3 kinase inhibitor with an 50 of 50 nM. Flt-3 Inhibitor III shows less active against other kinases. Flt-3 Inhibitor III has anticancer effects[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FLT3
Target	IC50: 50 nM (FLT3 kinase)[1]
In Vitro	Flt-3 Inhibitor III（化合物 4）也抑制 c-Kit、KDR、c-Abl、CDK1、c-Src 和 Tie-2，IC50 值分别为 0.26 µM、0.91 µM、1.2 µM、2.1 µM、2.8 µM 和 8.0 µM[1]。 Flt-3 Inhibitor III（化合物 4）阻断 BaF3-ITD、BaF3-D835/Y 和 MV4:11 细胞的增殖，IC50 值分别为 0.24 µM、0.76 µM 和 0.052 µM[1] 。
References	[1]. Pascal Furet, et al. Aromatic interactions with phenylalanine 691 and cysteine 828: a concept for FMS-like tyrosine kinase-3 inhibition. Application to the discovery of a new class of potential antileukemia agents. J Med Chem. 2006 Jul 27;49(15):4451-4.