1919050-87-5

1919050-87-5 structure

Name: RL648_81
Chemical Name: RL648_81
CAS Number: 1919050-87-5
Molecular Formula: C₁₇H₁₇F₄N₃O₂
Molecular Weight: 371.33
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Potassium Channel
Create Date: 2021-01-13 12:23:30
Modify Date: 2025-10-19 13:14:05
RL648_81 is a specific KQT-like subfamily 2/3 (KCNQ2/3) activator with an EC50 of 190 nM. RL648_81 robustly shifts the V1/2 of KCNQ2/3 channels towards hyperpolarized potentials.RL648_81 does not shift the V1/2 of either KCNQ4 or KCNQ5.RL648_81 has the potential for neurologic disorders associated with neuronal hyperexcitability research[1].

Name	RL648_81
Synonyms	Carbamic acid, N-[2-amino-3-fluoro-4-[[[4-(trifluoromethyl)phenyl]methyl]amino]phenyl]-, ethyl ester Ethyl (2-amino-3-fluoro-4-((4-(trifluoromethyl)benzyl)amino)phenyl)carbamate Ethyl (2-amino-3-fluoro-4-{[4-(trifluoromethyl)benzyl]amino}phenyl)carbamate RL648_81

Description	RL648_81 is a specific KQT-like subfamily 2/3 (KCNQ2/3) activator with an EC50 of 190 nM. RL648_81 robustly shifts the V1/2 of KCNQ2/3 channels towards hyperpolarized potentials.RL648_81 does not shift the V1/2 of either KCNQ4 or KCNQ5.RL648_81 has the potential for neurologic disorders associated with neuronal hyperexcitability research[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
References	[1]. Manoj Kumar, et al. Synthesis and Evaluation of Potent KCNQ2/3-Specific Channel Activators. Mol Pharmacol. 2016 Jun;89(6):667-77.