1800066-24-3

1800066-24-3 structure

Name: HPB
Chemical Name: HPB
CAS Number: 1800066-24-3
Molecular Formula: C₁₈H₂₀N₂O₄
Molecular Weight: 328.362
Catalog: Signaling Pathways Cell Cycle/DNA Damage HDAC
Create Date: 2021-01-09 18:08:58
Modify Date: 2024-01-02 14:01:44
HPB (HDAC6 inhibitor HPB) is a selective HDAC6 inhibitor with an IC50 of 31 nM. HPB exhibits >30-flod selectivity for HDAC6 over HDAC1[1].

Name	HPB
Synonyms	N-Hydroxy-4-{[(2-hydroxyethyl)(phenylacetyl)amino]methyl}benzamide N-Hydroxy-4-((N-(2-hydroxyethyl)-2-phenylacetamido)methyl)benzamide HPB Benzeneacetamide, N-[[4-[(hydroxyamino)carbonyl]phenyl]methyl]-N-(2-hydroxyethyl)-

Description	HPB (HDAC6 inhibitor HPB) is a selective HDAC6 inhibitor with an IC50 of 31 nM. HPB exhibits >30-flod selectivity for HDAC6 over HDAC1[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> Epigenetics >> HDAC
Target	HDAC6:31 nM (IC50) HDAC1:1130 nM (IC50)
References	[1]. Nicholas J Porter, et al. Unusual zinc-binding mode of HDAC6-selective hydroxamate inhibitors. Proc Natl Acad Sci U S A. 2017 Dec 19;114(51):13459-13464.