1214886-31-3

1214886-31-3 structure

Name: 4-oxo-27-TBDMS Withaferin A
Chemical Name: 4-oxo-27-TBDMS Withaferin A
CAS Number: 1214886-31-3
Molecular Formula: C₃₄H₅₀O₆Si
Molecular Weight: 582.843
Create Date: 2021-01-10 08:03:23
Modify Date: 2024-01-12 16:57:49
27-TBDMS-4-Dehydrowithaferin A, a withaferin A derivative, exhibits potent antiproliferative effects on the tumor cells.27-TBDMS-4-Dehydrowithaferin A induces tumor cells apoptosis. 27-TBDMS-4-Dehydrowithaferin A is a anticancer agent[1].

Name	4-oxo-27-TBDMS Withaferin A
Synonyms	Ergosta-2,24-diene-1,4,26-trione, 27-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5,6:22,26-diepoxy-, (5β,6β,22R)- 4-oxo-27-TBDMS Withaferin A (5β,6β,22R)-27-{[Dimethyl(2-methyl-2-propanyl)silyl]oxy}-5,6:22,26-diepoxyergosta-2,24-diene-1,4,26-trione

Description	27-TBDMS-4-Dehydrowithaferin A, a withaferin A derivative, exhibits potent antiproliferative effects on the tumor cells.27-TBDMS-4-Dehydrowithaferin A induces tumor cells apoptosis. 27-TBDMS-4-Dehydrowithaferin A is a anticancer agent[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
In Vitro	27-TBDMS-4-Dehydrowithaferin A (compound 9b; 48 h) exhibits potent antiproliferative effects on HeLa (IC50=1.7 μM), A-549 (IC50=5.3 μM), MCF-7 (IC50=0.5 μM), and normal Vero cells (IC50=3.1 μM)[1]. 27-TBDMS-4-Dehydrowithaferin A (24 μM; 48 h) activates caspase-3 in HeLa cells[1]. 27-TBDMS-4-Dehydrowithaferin A (8 μM; 1-4 h) with a longer incubation period (2-4 h) leads to apoptosis, effect that was maintained at concentrations of 12 and 16 μM[1].
References	[1]. Gabriel G Llanos, et al. Withaferin A-related steroids from Withania aristata exhibit potent antiproliferative activity by inducing apoptosis in human tumor cells. Eur J Med Chem. 2012 Aug;54:499-511.