172889-49-5

172889-49-5 structure

Name: CSP1
Chemical Name: CSP1
CAS Number: 172889-49-5
Molecular Formula: C₁₀₃H₁₆₈N₃₀O₂₄S
Molecular Weight: 2242.69
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2020-12-31 17:12:49
Modify Date: 2024-01-11 13:55:39
CSP1 is a potent and selective ComD1 receptor agonist, with an IC50 of 10.3 nM. CSP1 is a major variants of competence-stimulating peptide (CSP), and it can regulate genetic transformation of S. pneumonia by modulating quorum sensing (QS). CSP1 can act as an antibacterial agent[1][2].

Name	CSP1

Description	CSP1 is a potent and selective ComD1 receptor agonist, with an IC50 of 10.3 nM. CSP1 is a major variants of competence-stimulating peptide (CSP), and it can regulate genetic transformation of S. pneumonia by modulating quorum sensing (QS). CSP1 can act as an antibacterial agent[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
Target	IC50: 10.3 nM (ComD1 receptor)[1]
References	[1]. Yang Y, et, al. Structural Characterization of Competence-Stimulating Peptide Analogues Reveals Key Features for ComD1 and ComD2 Receptor Binding in Streptococcus pneumonia. Biochemistry. 2018 Sep 11;57(36):5359-5369. [2]. Johnsborg O, et, al. A hydrophobic patch in the competence-stimulating Peptide, a pneumococcal competence pheromone, is essential for specificity and biological activity. J Bacteriol. 2006 Mar; 188(5): 1744-9.

Molecular Formula	C₁₀₃H₁₆₈N₃₀O₂₄S
Molecular Weight	2242.69