332179-76-7
332179-76-7 structure
- Name: RGD-4C trifluoroacetate salt
- Chemical Name: RGD-4C trifluoroacetate salt
- CAS Number: 332179-76-7
- Molecular Formula: C42H60N14O16S4
- Molecular Weight: 1145.29
- Catalog: Signaling Pathways Cytoskeleton Integrin
- Create Date: 2020-09-14 17:12:10
- Modify Date: 2025-08-27 15:22:00
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RGD-4C is a arginine-glycine-aspartic acid peptide (ACDCRGDCFC) with integrin binding activity. The Arg-Gly-Asp (RGD) sequence serves as the primary integrin recognition site in extracellular matrix proteins, and peptides containing this sequence can mimic the recognition specificity of the matrix proteins. RGD-4C is a αv-integrin ligand, can conjugate with bioactive molecule to exert antitumor effects in animal models[1][2][3].
| Name | RGD-4C trifluoroacetate salt |
|---|
| Description | RGD-4C is a arginine-glycine-aspartic acid peptide (ACDCRGDCFC) with integrin binding activity. The Arg-Gly-Asp (RGD) sequence serves as the primary integrin recognition site in extracellular matrix proteins, and peptides containing this sequence can mimic the recognition specificity of the matrix proteins. RGD-4C is a αv-integrin ligand, can conjugate with bioactive molecule to exert antitumor effects in animal models[1][2][3]. |
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| Related Catalog | |
| In Vitro | RGD-4C (2.5, 5, 10 μg/mL) inhibits BAE cell proliferation by synthetic form modified with endostatin-derived peptides[2]. |
| In Vivo | RGD-4C (9.11 mg/kg; injection; single dose) inhibits the growth of B16F10 mouse melanoma in vivo[2]. Modified RGD-4C fused with the N-terminus of plant-derived single-chain ribosome inactivating protein saporin (SAP) (called RGD-SAP), (diluted in sodium chloride, 0.9%; i.v.; 200 µL; every 5 days, for 3 times) exerts anti-tumor activity in a model of muscle invasive bladder cancer[3]. RGD-SAP in combination with mitomycin C, a chemotherapeutic drug, increases the survival of mice bearing orthotopic bladder cancer with no evidence of systemic toxicity[3]. |
| References |
| Molecular Formula | C42H60N14O16S4 |
|---|---|
| Molecular Weight | 1145.29 |