2244684-42-0

2244684-42-0 structure

2244684-42-0 structure

Name: VH 032, phenol
Chemical Name: VH032-OH
CAS Number: 2244684-42-0
Molecular Formula: C₂₄H₃₂N₄O₅S
Molecular Weight: 488.60
Catalog: Signaling Pathways PROTAC Ligand for E3 Ligase
Create Date: 2020-08-08 09:20:59
Modify Date: 2024-01-14 09:03:07
VH032-OH is the VH032-based VHL ligand. VH032-OH can be connected to the ligand for protein by a linker to form PROTACs[1].

Name	VH032-OH

Description	VH032-OH is the VH032-based VHL ligand. VH032-OH can be connected to the ligand for protein by a linker to form PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> Ligand for E3 Ligase
Target	VHL
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References	[1]. Maniaci C, et al. Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation. Nat Commun. 2017;8(1):830. Published 2017 Oct 10.

Molecular Formula	C₂₄H₃₂N₄O₅S
Molecular Weight	488.60

Hazard Codes	Xi