127999-44-4

127999-44-4 structure

Name: Tolytoxin
Chemical Name: Tolytoxin
CAS Number: 127999-44-4
Molecular Formula: C₄₆H₇₅NO₁₃
Molecular Weight: 850.09
Catalog: Signaling Pathways Anti-infection Fungal
Create Date: 2020-08-11 18:09:17
Modify Date: 2024-01-09 06:41:21
Tolytoxin, a bioactive metabolite from cyanobacteria, is a potent antifungal antibiotic, exhibiting MICs of 0.25-8 nmol. Tolytoxin is a cyanobacterial macrolide that targets actin by inhibition of its polymerization. Tolytoxin has cytotoxic effects in cancer cells[1].

Name	Tolytoxin

Description	Tolytoxin, a bioactive metabolite from cyanobacteria, is a potent antifungal antibiotic, exhibiting MICs of 0.25-8 nmol. Tolytoxin is a cyanobacterial macrolide that targets actin by inhibition of its polymerization. Tolytoxin has cytotoxic effects in cancer cells[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal Signaling Pathways >> Antibody-drug Conjugate >> ADC Cytotoxin
In Vivo	Tolytoxin is highly toxic to mice, exhibiting an LD50 (ip) of 1.5 mg/kg.
References	[1]. G M Patterson, et al. Biological effects of tolytoxin (6-hydroxy-7-O-methyl-scytophycin b), a potent bioactive metabolite from cyanobacteria. Arch Microbiol. 1992;157(5):406-10. [2]. Aysegul Dilsizoglu Senol, et al. Effect of tolytoxin on tunneling nanotube formation and function. Sci Rep. 2019 Apr 5;9(1):5741.

Molecular Formula	C₄₆H₇₅NO₁₃
Molecular Weight	850.09