2320930-10-5

2320930-10-5 structure

Name: SSM 3 trifluoroacetate
Chemical Name: SSM3 tetraTFA
CAS Number: 2320930-10-5
Molecular Formula: C₃₀H₃₆F₁₂N₁₂O₁₀
Molecular Weight: 952.66
Catalog: Research Areas Infection
Create Date: 2020-08-11 16:47:32
Modify Date: 2024-01-09 16:53:33
SSM3 tetraTFA is a potent synthetic furin inhibitor with an EC50 and a Ki of 54 nM and 12 nM, respectively. SSM3 tetraTFA is able to block furin-dependent cell surface processing of anthrax protective antigen-83 in vitro[1][2].

Name	SSM3 tetraTFA

Description	SSM3 tetraTFA is a potent synthetic furin inhibitor with an EC50 and a Ki of 54 nM and 12 nM, respectively. SSM3 tetraTFA is able to block furin-dependent cell surface processing of anthrax protective antigen-83 in vitro[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Others >> Others
Target	EC50: 54 nM (furin) Ki: 12 nM (furin)[1]
In Vitro	SSM3 tetraTFA is against furin cleavage of the Pyr-RTKR-AMC substrate with an EC50 of 54 nM in vitro cleavage assays and cell-based tests[2]. SSM3 tetraTFA (0.1-25 μM) inhibits the furin-dependent conversion of PA83 into PA63 in a dose dependent manner, it inhibits PA83 processing in the cleavage reactions[2]. SSM3 tetraTFA shows comparable potency against furin (Ki=0.012 μM) and PC6B (Ki=0.004 μM), these compounds preferentially inhibited furin over PACE4 (Ki=0.041 μM) by 2- to 10-fold and over PC7 (Ki=0.595 μM) by 11- to 76-fold. In addition, it inhibits LF (Ki=1.241 μM) 25- to 167-fold less effectively than in furin and shows no measurable inhibition against trypsin and MT1-MMP[2].
References	[1]. Albert G Remacle, et al. Selective and Potent Furin Inhibitors Protect Cells From Anthrax Without Significant Toxicity. Int J Biochem Cell Biol [2]. Guan-Sheng Jiao, et al. Synthetic Small Molecule Furin Inhibitors Derived From 2,5-dideoxystreptamine. Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19707-12.

Molecular Formula	C₃₀H₃₆F₁₂N₁₂O₁₀
Molecular Weight	952.66