1384984-31-9
1384984-31-9 structure
- Name: SPR720
- Chemical Name: SPR720
- CAS Number: 1384984-31-9
- Molecular Formula: C21H26FN6O6P
- Molecular Weight: 508.44
- Catalog: Signaling Pathways Anti-infection Bacterial
- Create Date: 2020-08-11 07:28:52
- Modify Date: 2025-08-25 12:25:53
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SPR720 (pVXc-486) is an orally active and potent phosphate prodrug of SPR719 (VXc-486; HY-12930). SPR720 has potent bactericidal activities in vivo[1].
| Name | SPR720 |
|---|
| Description | SPR720 (pVXc-486) is an orally active and potent phosphate prodrug of SPR719 (VXc-486; HY-12930). SPR720 has potent bactericidal activities in vivo[1]. |
|---|---|
| Related Catalog | |
| In Vivo | SPR720 (pVXc-486; oral gavage; 10, 30, 100 mg/kg; once per day; 5 times per week for 4 weeks) reduces the mycobacterial burden in a model of chronic tuberculosis infection in mice[1]. SPR720 (oral; 100 mg/kg; once per day; 5 days per week, for 8 weeks) improves the bactericidal activities of antimycobacterial drugs[1]. Animal Model: Six-week old female BALB/c and C57BL/6 mice uninfected or M. tuberculosis-infected (Erdman)[1] Dosage: 10, 30, 100 mg/kg Administration: Oral gavage; once per day; 5 times per week for 4 weeks Result: Reduced the mycobacterial burden in a model of chronic tuberculosis infection in mice. |
| References |
| Molecular Formula | C21H26FN6O6P |
|---|---|
| Molecular Weight | 508.44 |