2250019-95-3

2250019-95-3 structure

Name: Nvs-pak1-c
Chemical Name: NVS-PAK1-C
CAS Number: 2250019-95-3
Molecular Formula: C₂₂H₂₃ClF₃N₅O
Molecular Weight: 465.90
Catalog: Signaling Pathways Cell Cycle/DNA Damage PAK
Create Date: 2020-08-07 20:51:25
Modify Date: 2024-01-09 10:20:18
NVS-PAK1-C is a potent, ATP-competitive and specific allosteric PAK1 inhibitor probe with IC50 values of 5 nM and 6 nM for dephosphorylated PAK1 and phosphorylated PAK1, respectively. NVS-PAK1-C is also against dephosphorylated PAK2 (IC50=270 nM) and phosphorylated PAK2 (IC50=720 nM)[1].

Name	NVS-PAK1-C

Description	NVS-PAK1-C is a potent, ATP-competitive and specific allosteric PAK1 inhibitor probe with IC50 values of 5 nM and 6 nM for dephosphorylated PAK1 and phosphorylated PAK1, respectively. NVS-PAK1-C is also against dephosphorylated PAK2 (IC50=270 nM) and phosphorylated PAK2 (IC50=720 nM)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cytoskeleton >> PAK Signaling Pathways >> Cell Cycle/DNA Damage >> PAK
Target	PAK1:0.007 μM (Kd) PAK2:0.4 μM (Kd) PAK1:5 nM (IC50) PAK2:270 nM (IC50)
In Vitro	NVS-PAK1-1 potently inhibits autophosphorylation of PAK1 (S144) at 0.25 µM in the Su86.86 cell line and MEK S289 phosphorylation with an IC50=0.21 µM in Su86.86 cells in which PAK2 is downregulated[1].
References	[1]. NVS-PAK1-1 A Chemical Probe For PAK1

Molecular Formula	C₂₂H₂₃ClF₃N₅O
Molecular Weight	465.90