1630160-25-6

1630160-25-6 structure

Name: ML338
Chemical Name: ML338
CAS Number: 1630160-25-6
Molecular Formula: C₁₇H₁₂ClN₅OS
Molecular Weight: 369.83
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2020-08-11 18:10:12
Modify Date: 2025-08-25 13:21:36
ML338 is a selective small molecule inhibitor probe of non-replicating Mycobacterium tuberculosis bacilli and is against the non-replicating M. tuberculosis with IC90 and IC99 values of 1 μM and 4 μM, respectively by CFU. ML338 is a invaluable tool for identifying both essential functions and vulnerabilities of the M. tuberculosis bacilli in the nutrient deprivation states. ML338 can be used for the study of M. tuberculosis chemotherapy[1].

Name	ML338

Description	ML338 is a selective small molecule inhibitor probe of non-replicating Mycobacterium tuberculosis bacilli and is against the non-replicating M. tuberculosis with IC90 and IC99 values of 1 μM and 4 μM, respectively by CFU. ML338 is a invaluable tool for identifying both essential functions and vulnerabilities of the M. tuberculosis bacilli in the nutrient deprivation states. ML338 can be used for the study of M. tuberculosis chemotherapy[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
Target	IC90: 1 μM (non-replicating Mycobacterium tuberculosis bacilli) IC99: 4 μM (non-replicating Mycobacterium tuberculosis bacilli)
In Vitro	ML338 (0-50 μM) has potency and selectivity against non-replicating M. tuberculosis with an IC90 of 1 μM. Additionally, ML338 have an IC99 against non-replicating M. tuberculosis (4 μM) which is excellent relative to current TB drugs[1]. ML338 (0-50 μM; 48 hours) shows no toxicity to J774 macrophage cells up to 50 μM, the highest concentration[1]. ML338 is against the non-replicating M. tuberculosis with IC90 and IC99 velues of 1 μM and 4 μM, respectively by CFU. Additionally, it against the replicating M. tuberculosis with IC90 and IC99 velues of 62 μM and 62 μM, respectively by CFU[1].
References	[1]. Partha P. Nag,et al. Elucidation of the Physiology of Non-Replicating, Drug Tolerant Mycobacterium tuberculosis With the Aid of the Small Molecule Probe ML338. Review

Molecular Formula	C₁₇H₁₂ClN₅OS
Molecular Weight	369.83