Shanghai Nianxing Industrial Co., Ltd
China
Product Name: CRA-2059
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256649-36-2

256649-36-2 structure

256649-36-2 structure

Name: CRA-2059
Chemical Name: CRA-2059
CAS Number: 256649-36-2
Molecular Formula: C₃₄H₄₆N₁₂O₈
Molecular Weight: 750.80
Catalog: Signaling Pathways Metabolic Enzyme/Protease Ser/Thr Protease
Create Date: 2020-08-07 18:39:55
Modify Date: 2025-08-26 19:17:26
CRA-2059 is a highly specific and selective tryptase inhibitor, with a Ki of 620 pM for recombinant human tryptase-β (rHTβ)[1][2].

Name	CRA-2059

Description	CRA-2059 is a highly specific and selective tryptase inhibitor, with a Ki of 620 pM for recombinant human tryptase-β (rHTβ)[1][2].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Ser/Thr Protease Research Areas >> Inflammation/Immunology
In Vitro	Tryptase is a trypsin-like serine protease found as a major protein component in human mast cell secretory granules. CRA-2059 has the potential for inflammatory bowel disease research[1].
References	[1]. Tremaine WJ, et al. Treatment of mildly to moderately active ulcerative colitis with a tryptase inhibitor (APC 2059): an open-label pilot study. Aliment Pharmacol Ther. 2002;16(3):407-413. [2]. Selwood T, et al. Potent bivalent inhibition of human tryptase-beta by a synthetic inhibitor. Biol Chem. 2003;384(12):1605-1611.

Molecular Formula	C₃₄H₄₆N₁₂O₈
Molecular Weight	750.80

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