1071098-42-4
1071098-42-4 structure
- Name: AZA1
- Chemical Name: AZA1
- CAS Number: 1071098-42-4
- Molecular Formula: C22H20N6
- Molecular Weight: 368.43
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2020-08-11 12:15:24
- Modify Date: 2024-01-12 16:42:54
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AZA1 is a potent dual inhibitor of Rac1 and Cdc42. AZA1 induces prostate cancer cells apoptosis and inhibits prostate cancer cells proliferation, migration and invasion[1][2].
| Name | AZA1 |
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| Description | AZA1 is a potent dual inhibitor of Rac1 and Cdc42. AZA1 induces prostate cancer cells apoptosis and inhibits prostate cancer cells proliferation, migration and invasion[1][2]. |
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| Related Catalog | |
| In Vitro | AZA1 (Rac1/Cdc42-IN-1) (2-10 μM; 72 hours) blocks the proliferation of human prostate cancer cells 22Rv1 prostate cancer cells[1]. AZA1 (2-10 μM; 24 hours) reduces phosphorylation of PAK1, AKT and BAD in EGF-stimulated 22Rv1 prostate cancer cells[1]. AZA1 (10 μM; 24 hours) blocks Rac1 and Cdc42-dependent cell cycle events in 22Rv1 prostate cancer cells[1]. AZA1 blocks Rac1 and Cdc42-dependent migration of 22Rv1, DU 145 and PC-3 prostate cancer cells[1]. AZA1 affects cell motility and actin rearrangement in prostate cancer cells by suppressing Rac1 and Cdc42 activity via PAK1/2 phosphorylation[1]. Cell Proliferation Assay[1] Cell Line: 22Rv1 prostate cancer cells Concentration: 2, 5, 10 μM Incubation Time: 72 hours Result: Suppressed 22Rv1 prostate cancer cell proliferation in both unstimulated and EGF-stimulated cancer cells in a dose-dependent manner. Western Blot Analysis[1] Cell Line: 22Rv1 prostate cancer cells (EGF-stimulated) Concentration: 2, 5, 10 μM Incubation Time: 24 hours Result: Reduced phosphorylation of PAK1, AKT and BAD in EGF-stimulated 22Rv1 prostate cancer cells. |
| In Vivo | AZA1 (Rac1/Cdc42-IN-1) (100 μg; i.p.; daily for 2 weeks) is potent in suppressing human 22Rv1 xenograft growth in mice and improving survival[1]. Animal Model: 5 week-old athymic nu/nu (nude) mice (bearing 22Rv1 prostate cancer cell xenografts)[1] Dosage: 100 μg in 100 µl 30% DMSO Administration: I.p.; daily for 2 weeks Result: The suppressive effect of AZA1 on tumor growth was significant. |
| References |
| Molecular Formula | C22H20N6 |
|---|---|
| Molecular Weight | 368.43 |
| Storage condition | 2-8°C |