327031-55-0

327031-55-0 structure

Name: VLX600
Chemical Name: VLX600
CAS Number: 327031-55-0
Molecular Formula: C₁₇H₁₅N₇
Molecular Weight: 317.35
Catalog: Signaling Pathways Autophagy Autophagy
Create Date: 2020-06-01 15:48:16
Modify Date: 2025-08-25 14:02:59
VLX600 is an iron-chelating inhibitor of oxidative phosphorylation (OXPHOS). VLX600 causes mitochondrial dysfunction and induces a strong shift to glycolysis. VLX600 displays selective cytotoxic activity against malignant cell and induces autophagy. Anticancer activity[1][2].

Name	VLX600
Synonyms	MFCD01305422

Description	VLX600 is an iron-chelating inhibitor of oxidative phosphorylation (OXPHOS). VLX600 causes mitochondrial dysfunction and induces a strong shift to glycolysis. VLX600 displays selective cytotoxic activity against malignant cell and induces autophagy. Anticancer activity[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Autophagy >> Autophagy
In Vitro	VLX600 (6 μM; 72 hours) induces an autophagic response[2]. VLX600 is cytotoxic to HCT116 spheroids. VLX600 induces a HIF-1α-dependent glycolytic response. VLX600 inhibits oxygen consumption in HCT116 cells. VLX600 inhibits phosphorylation of the mTOR downstream effectors 4EBP1 and p70-S6K by an HIF-1α-independent mechanism. VLX600 preferentially leads to decreased ATP levels in cancer but not normal cells[2]. Cell Proliferation Assay[2] Cell Line: HCT116, HT29, SW620, HT8, DLD and RKO cells Concentration: 0.1, 1, 10, 100μM Incubation Time: 72 hours Result: Inhibited the proliferation of these cells. Western Blot Analysis[2] Cell Line: HCT116 cells Concentration: 6 μM Incubation Time: 72 hours Result: LC3-II was induced.
In Vivo	VLX600 (16 mg/kg; i.v.; every third day for 16 days) shows anti-tumor activity in human tumor xenografts[2]. Animal Model: NMRI nu/nu mice (HCT116 and HT29 colon cancer xenografts)[2] Dosage: 16 mg/kg Administration: Intravenously; every third day for 16 days Result: Anti-tumor activity was observed in both HCT116 and HT29 colon cancer xenografts.
References	[1]. Karlsson H, et al. A novel tumor spheroid model identifies selective enhancement of radiation by an inhibitor of oxidative phosphorylation. Oncotarget. 2019 Sep 3;10(51):5372-5382. [2]. Zhang X, et al. Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments. Nat Commun. 2014;5:3295.

Molecular Formula	C₁₇H₁₅N₇
Molecular Weight	317.35

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