1801765-04-7
1801765-04-7 structure
- Name: TNO155
- Chemical Name: TNO155
- CAS Number: 1801765-04-7
- Molecular Formula: C18H24ClN7OS
- Molecular Weight: 421.95
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphatase
- Create Date: 2020-06-01 18:14:52
- Modify Date: 2024-01-02 21:43:07
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TNO155 is a potent selective and orally active allosteric inhibitor of wild-type SHP2 (IC50=0.011 µM). TNO155 has the potential for the study of RTK-dependent malignancies, especially advanced solid tumors[1].
| Name | TNO155 |
|---|---|
| Synonyms | MFCD32693919 |
| Description | TNO155 is a potent selective and orally active allosteric inhibitor of wild-type SHP2 (IC50=0.011 µM). TNO155 has the potential for the study of RTK-dependent malignancies, especially advanced solid tumors[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 0.011 µM (SHP2)[1] |
| In Vitro | TNO155 shows an IC50 of 0.008 µM in KYSE520 pERK assay and shows an IC50 of 0.100 µM in KYSE520 5-day cell proliferation assay. The off-target IC50 values are 18 µM, 6.9 µM, and 11 µM for Cav1.2, VMAT, and SST3, respectively[1]. |
| In Vivo | The oral bioavailability in mouse, rat and money are 78%, 86%, and 60%, respectively[1]. |
| References |
| Molecular Formula | C18H24ClN7OS |
|---|---|
| Molecular Weight | 421.95 |