2093386-51-5

2093386-51-5 structure

Name: Thalidomide-NH-C6-NH2 TFA
Chemical Name: Thalidomide-NH-C6-NH2 TFA
CAS Number: 2093386-51-5
Molecular Formula: C₂₁H₂₅F₃N₄O₆
Molecular Weight: 486.44
Catalog: Signaling Pathways PROTAC E3 Ligase Ligand-Linker Conjugate
Create Date: 2020-06-01 19:13:45
Modify Date: 2025-08-27 11:30:40
Thalidomide-NH-C6-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].

Name	Thalidomide-NH-C6-NH2 TFA

Description	Thalidomide-NH-C6-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References	[1]. Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem. 2019 Sep 12;62(17):8152-8163.

Molecular Formula	C₂₁H₂₅F₃N₄O₆
Molecular Weight	486.44

Hazard Codes	Xi