956613-01-7
956613-01-7 structure
- Name: SB-633825
- Chemical Name: SB-633825
- CAS Number: 956613-01-7
- Molecular Formula: C28H25N3O3S
- Molecular Weight: 483.58
- Catalog: Research Areas Cardiovascular Disease
- Create Date: 2020-06-01 17:14:21
- Modify Date: 2024-01-29 11:20:09
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SB-633825 is a potent and ATP-competitive inhibitor of TIE2, LOK (STK10) and BRK with IC50s of 3.5 nM, 66 nM, 150 nM, respectively. SB-633825 can inhibit cancer cell growth and angiogenesis[1].
| Name | SB-633825 |
|---|
| Description | SB-633825 is a potent and ATP-competitive inhibitor of TIE2, LOK (STK10) and BRK with IC50s of 3.5 nM, 66 nM, 150 nM, respectively. SB-633825 can inhibit cancer cell growth and angiogenesis[1]. |
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| Related Catalog | |
| Target |
IC50: 3.5 nM (TIE2), 66 nM (LOK) and 150 nM (BRK)[1] |
| In Vitro | SB-633825 inhibits TIE2 Tyrosine-protein kinase (TIE2), lymphocyte-oriented kinase (LOK; STK10) and breast tumor kinase (Brk; PTK6)[1]. SB-633825 inhibits LOK to 44% maximal activity and TIE2 to 75% maximal activity at 0.1 µM[1]. |
| References |
| Molecular Formula | C28H25N3O3S |
|---|---|
| Molecular Weight | 483.58 |
| Hazard Codes | Xi |
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