1087784-71-1
1087784-71-1 structure
- Name: Metallo β-lactamase ligand 1
- Chemical Name: Metallo β-lactamase ligand 1
- CAS Number: 1087784-71-1
- Molecular Formula: C7H9NO5S
- Molecular Weight: 219.22
- Catalog: Signaling Pathways Anti-infection Bacterial
- Create Date: 2020-06-01 17:47:57
- Modify Date: 2024-01-08 16:03:59
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Metallo-beta-lactamase ligand 1 is a class B β-lactamase inhibitor with antibacterial activity extracted from patent WO2019221122A1, compound A[1].
| Name | Metallo β-lactamase ligand 1 |
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| Description | Metallo-beta-lactamase ligand 1 is a class B β-lactamase inhibitor with antibacterial activity extracted from patent WO2019221122A1, compound A[1]. |
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| Related Catalog | |
| In Vitro | One effective measure against β-lactam antibacterial resistant bacteria is to use an inhibitor of β-lactamase, the enzyme responsible for its resistance mechanism, together with an appropriate β-lactam antibacterial agent[1]. The toxicity of Metallo-beta-lactamase ligand 1 (Compound A) is extremely low in HeLa cells[1]. |
| In Vivo | After infecting mice with an experimental strain (E. coli strain into which a plasmid encoding class B β-lactamase (IMP-1) is introduced), Metallo-beta-lactamase ligand 1 (compound A; 100 mg/kg; intraperitoneal injection) is administered, and life and death are observed. Administration of Metallo-beta-lactamase ligand 1 (compound A) significantly improves the survival rate[1]. |
| References |
[1]. Arakawa, Yoshichika, et al.β-LACTAMASE INHIBITOR. WO2019221122A1. |
| Molecular Formula | C7H9NO5S |
|---|---|
| Molecular Weight | 219.22 |