Shanghai Nianxing Industrial Co., Ltd
China
Product Name: GSK-2793660
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1613458-70-0

1613458-70-0 structure

1613458-70-0 structure

Name: GSK-2793660
Chemical Name: GSK-2793660
CAS Number: 1613458-70-0
Molecular Formula: C₂₀H₂₇N₃O₃
Molecular Weight: 357.45
Catalog: Signaling Pathways Metabolic Enzyme/Protease Cathepsin
Create Date: 2020-06-01 18:14:05
Modify Date: 2024-04-02 19:15:04
GSK-2793660 is an oral, irreversible inhibitor of Cathepsin C (CTSC). GSK-2793660 can be used for the research of bronchiectasis[1][2].

Name	GSK-2793660

Description	GSK-2793660 is an oral, irreversible inhibitor of Cathepsin C (CTSC). GSK-2793660 can be used for the research of bronchiectasis[1][2].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Metabolic Enzyme/Protease >> Cathepsin
Target	Cathepsin C (CTSC)[1][2]
In Vivo	GSK-2793660 is a cathepsin C (also known as dipeptidyl peptidase I enzyme) inhibitor for the reaearch of cystic fibrosis, non-cystic fibrosis bronchiectasis, anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis and bronchiectasis[1].
References	[1]. Szcześniak P, et al. The Synthesis of α,α-Disubstituted α-Amino Acids via Ichikawa Rearrangement. J Org Chem. 2016 Feb 5;81(3):1057-74. [2]. Miller BE, et al. Epithelial desquamation observed in a phase I study of an oral cathepsin C inhibitor (GSK2793660). Br J Clin Pharmacol. 2017 Dec;83(12):2813-2820.

Molecular Formula	C₂₀H₂₇N₃O₃
Molecular Weight	357.45

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