2222844-89-3
2222844-89-3 structure
- Name: AZD-9833
- Chemical Name: AZD-9833
- CAS Number: 2222844-89-3
- Molecular Formula: C24H28F4N6
- Molecular Weight: 476.51
- Catalog: Signaling Pathways Others Estrogen Receptor/ERR
- Create Date: 2020-06-01 19:49:16
- Modify Date: 2024-01-07 16:50:37
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Estrogen receptor antagonist 2 is a potent and orally active estrogen receptor (ER) antagonist, example 17, extracted from patent US20180111931A1. Estrogen receptor antagonist 2 is used for the study of breast cancer[1].
| Name | AZD-9833 |
|---|
| Description | Estrogen receptor antagonist 2 is a potent and orally active estrogen receptor (ER) antagonist, example 17, extracted from patent US20180111931A1. Estrogen receptor antagonist 2 is used for the study of breast cancer[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: estrogen receptor (ER)[1] |
| In Vivo | Estrogen receptor antagonist 2 (oral administration; 0.2-50 mg/kg; 20 days) exhibits anti-tumour efficacy as a dose-dependent manner in human parental MCF7 mice xenograft[1]. Estrogen receptor antagonist 2 (oral administration; 0.8-40 mg/kg; 30 days) decreases tumor growth as a dose-dependent manner. It gives almost complete tumour growth inhibition at the doses >10 mg/kg in mice[1]. Animal Model: Human ESR1 mutant breast cancer patient derived xenograft with CTC174 cells in female NSG mice[1] Dosage: 0.8 mg/kg, 3 mg/kg, 10 mg/kg, 20 mg/kg, 40 mg/kg Administration: Oral administration; 30 days; once daily Result: Inhibited tumor growth in a dose-dependent manner. |
| References |
[1]. Bernard Christophe Barlaam, etal. Chemical compounds. Patent US20180111931. |
| Molecular Formula | C24H28F4N6 |
|---|---|
| Molecular Weight | 476.51 |