931395-42-5

931395-42-5 structure

Name: Dusquetide
Chemical Name: Dusquetide
CAS Number: 931395-42-5
Molecular Formula: C₂₅H₄₇N₉O₅
Molecular Weight: 553.70
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2020-06-02 01:42:34
Modify Date: 2025-08-25 11:24:34
Dusquetide (SGX942) is a first-in-class innate defense regulator (IDR). Dusquetide modulates the innate immune response to both PAMPs and DAMPs by binding to p62. Dusquetide shows activity in both reducing inflammation and increasing clearance of bacterial infection[1]. DAMPs: damage-associated molecular patterns; PAMPs: pathogen-associated molecular patterns

Name	Dusquetide

Description	Dusquetide (SGX942) is a first-in-class innate defense regulator (IDR). Dusquetide modulates the innate immune response to both PAMPs and DAMPs by binding to p62. Dusquetide shows activity in both reducing inflammation and increasing clearance of bacterial infection[1]. DAMPs: damage-associated molecular patterns; PAMPs: pathogen-associated molecular patterns
Related Catalog	Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
In Vivo	Dusquetide (SGX942) (25 mg/kg; i.v.; days 0, 4, 7, 10, and 14) shows no increase in tumor growth or worsening of survival and a trend towards decreased tumor growth and improvement in survival with radiation[1]. Animal Model: Female nude mice (MCF-7 tumor xenografts)[1] Dosage: 25 mg/kg Administration: I.v.; days 0, 4, 7, 10, and 14 Result: Showed no increase in tumor growth or worsening of survival and a trend towards decreased tumor growth and improvement in survival with radiation.
References	[1]. Kudrimoti M, et al. Dusquetide: A novel innate defense regulator demonstrating a significant and consistent reduction in the duration of oral mucositis in preclinical data and a randomized, placebo-controlled phase 2a clinical study. J Biotechnol. 2016 Dec 10;239:115-125.

Molecular Formula	C₂₅H₄₇N₉O₅
Molecular Weight	553.70