1219810-90-8

1219810-90-8 structure

Name: t-Boc-N-Amido-PEG4-propargyl
Chemical Name: Boc-N-Amido-PEG4-propargyl
CAS Number: 1219810-90-8
Molecular Formula: C₁₆H₂₉NO₆
Molecular Weight: 331.40
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2020-06-01 14:34:36
Modify Date: 2024-01-31 11:02:25
Boc-N-Amido-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	Boc-N-Amido-PEG4-propargyl

Description	Boc-N-Amido-PEG4-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs Alkyl/ether
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562