2387510-84-9
2387510-84-9 structure
- Name: AM12
- Chemical Name: AM12
- CAS Number: 2387510-84-9
- Molecular Formula: C15H9BrO5
- Molecular Weight: 349.13
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel TRP Channel
- Create Date: 2020-06-01 10:36:48
- Modify Date: 2024-01-06 18:24:56
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AM12 inhibits Lanthanide-evoked TRPC5 activity with an IC50 of 0.28 μM[1].
| Name | AM12 |
|---|
| Description | AM12 inhibits Lanthanide-evoked TRPC5 activity with an IC50 of 0.28 μM[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 0.28 μM (TRPC5)[1] |
| In Vitro | AM12 also inhibits TRPC5 activity evoked by the agonist (-)-Englerin A[1]. AM12 also inhibits TRPC4 channels similarly. AM12 inhibits TRPC5 and TRPC4 channels via a site accessible from the extracellular face of the membrane, acting directly on either the channel or a site closely associated with it[1]. AM12 also inhibits Ca2+ entry evoked by Gd3+. AM12 inhibits the Gd3+-evoked Ca2+ signal with an IC50 of 0.28 μM. AM12 is slightly more potent than the natural product Galangin as an inhibitor of the Gd3+-evoked signal[1]. |
| References |
| Molecular Formula | C15H9BrO5 |
|---|---|
| Molecular Weight | 349.13 |