740790-94-7
740790-94-7 structure
- Name: T-705RTP
- Chemical Name: T-705RTP
- CAS Number: 740790-94-7
- Molecular Formula: C10H15FN3O15P3
- Molecular Weight: 529.16
- Catalog: Signaling Pathways Anti-infection Influenza Virus
- Create Date: 2020-04-04 09:56:32
- Modify Date: 2025-08-26 18:03:20
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T-705RTP is a selective and GTP-competitive influenza virus RNA polymerase inhibitor with an IC50 of 0.14 μM and a Ki of 1.52 μM. T-705RTP is the active triphosphate metabolite of T-705 and has potent anti-influenza virus activity[1][2].
| Name | T-705RTP |
|---|
| Description | T-705RTP is a selective and GTP-competitive influenza virus RNA polymerase inhibitor with an IC50 of 0.14 μM and a Ki of 1.52 μM. T-705RTP is the active triphosphate metabolite of T-705 and has potent anti-influenza virus activity[1][2]. |
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| Related Catalog | |
| Target |
IC50: 0.14 μM (Influenza virus RNA polymerase)[1] Ki: 1.52 μM (Influenza virus RNA polymerase)[1] |
| In Vitro | T-705RTP and T-705RMP are detected in MDCK cells treated with T-705. T-705RTP inhibits influenza virus RNA polymerase activity in a dose-dependent and a GTP-competitive manner[1]. T-705RTP inhibits the incorporation of ATP and GTP in a competitive manner with Ki values of 7.72 and 1.56 μM, respectively. T-705RTP inhibits the incorporation of CTP in a mixed-type manner with a Ki value of 11.3 μM, and also inhibits the incorporation of UTP in a noncompetitive manner[2]. The incorporation of a single molecule of T-705RTP (10-1000 μM) inhibits influenza virus RNA strand extension[2]. |
| References |
| Molecular Formula | C10H15FN3O15P3 |
|---|---|
| Molecular Weight | 529.16 |