1597440-03-3

1597440-03-3 structure

Name: (Rac)-BRD0705
Chemical Name: (Rac)-BRD0705
CAS Number: 1597440-03-3
Molecular Formula: C₂₀H₂₃N₃O
Molecular Weight: 321.42
Catalog: Signaling Pathways PI3K/Akt/mTOR GSK-3
Create Date: 2020-04-20 07:16:04
Modify Date: 2024-01-13 16:37:28
(Rac)-BRD0705 is a less active racemate of BRD0705. BRD0705 is a potent, paralog selective and orally active GSK3α inhibitor with an IC50 of 66 nM and a Kd of 4.8 μM. BRD0705 displays increased selectivity for GSK3α (8-fold) versus GSK3β (IC50 of 515 nM). BRD0705 can be used for acute myeloid leukemia (AML)[1][2].

Name	(Rac)-BRD0705

Description	(Rac)-BRD0705 is a less active racemate of BRD0705. BRD0705 is a potent, paralog selective and orally active GSK3α inhibitor with an IC50 of 66 nM and a Kd of 4.8 μM. BRD0705 displays increased selectivity for GSK3α (8-fold) versus GSK3β (IC50 of 515 nM). BRD0705 can be used for acute myeloid leukemia (AML)[1][2].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> GSK-3 Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> GSK-3
References	[1]. Wagner FF, et al. Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia. Sci Transl Med. 2018 Mar 7;10(431). pii: eaam8460. [2]. Edward Scolnick, et al. Uses of paralog-selective inhibitors of gsk3 kinases. US20160375006A1.

Molecular Formula	C₂₀H₂₃N₃O
Molecular Weight	321.42